Sulfur amino acid catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Sulfur amino acid catabolic process pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher Sulfur amino acid catabolic process pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as PAAD and MESO, show the opposite pattern, with higher activity associated with better survival.

PAAD, CHOL, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	DFS	Tertile	All	0.683	0.356	.001	43	view →
CHOL	DFS	Tertile	II,III,IV	0.059	0.490	<.001	42	view →
MESO	DFS	Quartile	III,IV	0.458	0.233	.001	24	view →
LGG	DFS	Tertile	All	0.738	0.889	<.001	18	view →
ACC	DFS	Median	II,III,IV	0.727	0.516	.012	16	view →
KIRC	DFS	Median	All	0.542	0.706	.016	15	view →
PRAD	OS	Tertile	All	0.782	0.959	.024	12	view →
UCS	OS	Tertile	IV	1.000	0.323	.049	12	view →
READ	DFS	Quartile	III,IV	0.510	0.921	.015	12	view →
THCA	DFS	Median	III,IV	0.762	0.922	.009	10	view →
SKCM	DFS	Median	IV	0.111	0.694	.004	7	view →
BLCA	DFS	Median	IV	0.453	0.284	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0000098–PAAD (DFS)

Open the PAAD breakdown →