Sulfur amino acid catabolic process

Across TCGA cell cohorts, RNA activity of the Sulfur amino acid catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMO1, EBI3, and CSAD, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FMO1 grouped by Sulfur amino acid catabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FMO1 →	-0.248	-1.221	.002	.004	3	7
OVARY	EBI3 →	-0.314	-1.297	<.001	<.001	3	6
LUNG_SCLC	CSAD →	-0.303	-1.327	.002	.001	3	6
CNS	FGF18 →	-0.201	-0.907	.004	.001	3	5
PANCREAS	RPP25 →	-0.239	-1.677	<.001	<.001	3	5
CNS	CLSTN2 →	-0.348	-1.192	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FMO1 by Sulfur amino acid catabolic process activity — OESOPHAGUS

Explore this box plot interactively →