Sulfur amino acid catabolic process

Across TCGA cell cohorts, RNA activity of the Sulfur amino acid catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSC4D, GPR157, and OGDHL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SSC4D grouped by Sulfur amino acid catabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SSC4D →	+0.202	+1.593	<.001	.001	3	3
LUNG_NSCLC_LUSC	GPR157 →	+0.253	+1.958	.001	<.001	2	4
LUNG_NSCLC_LUSC	OGDHL →	+0.392	+1.593	.002	.001	3	3
SKIN	NRXN3 →	+0.149	+0.807	.001	.009	3	3
KIDNEY	EXD3 →	+0.227	+0.137	.003	.009	3	2
KIDNEY	CELA2B →	+0.214	+0.137	.009	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SSC4D by Sulfur amino acid catabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →