Sulfur amino acid catabolic process

Across TCGA cell cohorts, RNA activity of the Sulfur amino acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TST, MPST, and CRYL1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur amino acid catabolic process activity versus TST in STOMACH (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TST →	+1.641	+0.286	<.001	<.001	3	9
OESOPHAGUS	MPST →	+1.450	+1.177	<.001	.004	3	5
STOMACH	CRYL1 →	+1.664	+0.264	.004	<.001	3	5
STOMACH	CYP3A5 →	+3.030	+0.304	.002	.008	3	4
LUNG_NSCLC_LUAD	TMEM140 →	+0.569	+0.769	<.001	<.001	3	4
PANCREAS	MSRB2 →	+0.942	+0.885	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000098 vs TST — STOMACH

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