Sulfur amino acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Sulfur amino acid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MTAP, TK1, and PAK2_S55, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur amino acid biosynthetic process activity versus MTAP in GBM (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MTAP →	+0.463	+0.043	.004	.007	2	7
BRCA	TK1 →	-0.635	-0.043	<.001	<.001	3	5
CCRCC	PAK2_S55 →	+1.107	+0.054	.001	.001	3	5
OV	NECTIN4_S444 →	-0.898	-0.042	.004	.008	3	4
BRCA	ASPA →	+0.744	+0.038	<.001	.001	3	4
BRCA	STXBP1_S594 →	+1.117	+0.055	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000097 vs MTAP — GBM

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