Sulfur amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Sulfur amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHPRH, INPP5E, and GPR19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SHPRH grouped by Sulfur amino acid metabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SHPRH →	+1.254	+1.065	.003	.002	3	5
URINARY_TRACT	INPP5E →	+0.901	+1.913	<.001	<.001	3	4
URINARY_TRACT	GPR19 →	-1.492	-2.114	<.001	<.001	3	4
PANCREAS	UNC45A →	+0.518	+1.432	.003	<.001	3	4
STOMACH	EAF2 →	+1.325	+1.300	.005	<.001	3	4
CNS	GPNMB →	+3.586	+0.843	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SHPRH by Sulfur amino acid metabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →