Obsolete regulation of transcription involved in G1/S transition of mitotic cell cycle

pathway activity — cross-omics
GO:0000083Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Obsolete regulation of transcription involved in G1/S transition of mitotic cell cycle pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OSBPL8_S807, XPO4_S521, and XRCC1_T453, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADOSBPL8_S807 →-1.689-1.160<.001<.00135
LSCCXPO4_S521 →+0.900+0.517<.001<.00134
LUADXRCC1_T453 →-0.722-0.607<.001<.00134
OVCDK18_S117 →+0.757+0.594<.001.00534
OVCDK18_S89 →+0.672+0.859.001.00225
LUADCDK18_S98 →+0.694+0.670<.001<.00125
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration