DNA replication checkpoint signaling

Across TCGA patient cohorts, RNA activity of the DNA replication checkpoint signaling pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_T506, RFC2, and RFC4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA replication checkpoint signaling activity versus RFC1_T506 in LUAD (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFC1_T506 →	+1.314	+0.151	<.001	<.001	3	10
LSCC	RFC2 →	+0.405	+0.101	<.001	<.001	3	10
LSCC	RFC4 →	+0.489	+0.099	<.001	<.001	3	10
BRCA	RIF1_S782 →	+1.067	+0.096	<.001	<.001	3	10
HNSC	RRM1 →	+0.493	+0.106	<.001	<.001	3	10
LUAD	RRM2 →	+1.038	+0.141	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000076 vs RFC1_T506 — LUAD

Explore this scatter interactively →