Cell cycle checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Cell cycle checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGSM3, ATP5POP1, and SHANK2-AS3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell cycle checkpoint signaling activity versus SGSM3 in COAD (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SGSM3 →	-0.183	-1.013	.003	.005	3	1
COAD	ATP5POP1 →	+0.194	+1.310	.001	<.001	3	1
COAD	SHANK2-AS3 →	+0.105	+1.196	.006	.008	3	1
COAD	ATP6V0CP3 →	-0.458	-1.002	.004	.006	3	1
COAD	PRDX1P1 →	+0.799	+0.968	<.001	.009	3	1
COAD	SHMT1P1 →	+0.116	+1.525	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000075 vs SGSM3 — COAD

Explore this scatter interactively →