Ribosomal small subunit export from nucleus

Across TCGA cell cohorts, RNA activity of the Ribosomal small subunit export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GVQW3, SORBS2, and PPFIA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GVQW3 grouped by Ribosomal small subunit export from nucleus-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GVQW3 →	+0.562	+0.105	.004	.008	3	4
BREAST	SORBS2 →	+1.383	+0.064	.003	.002	3	4
OESOPHAGUS	PPFIA4 →	+1.491	+0.191	.001	.001	3	4
LIVER	MAP9 →	+2.763	+0.284	.002	.005	3	3
STOMACH	CDKN3 →	-0.962	-0.168	<.001	<.001	3	3
LUNG_NSCLC_LUAD	RFC4 →	-0.599	-0.105	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GVQW3 by Ribosomal small subunit export from nucleus activity — CNS

Explore this box plot interactively →