Ribosomal large subunit export from nucleus

Across TCGA patient cohorts, RNA activity of the Ribosomal large subunit export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPRD2, GATAD2B, and GABPA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal large subunit export from nucleus activity versus RPRD2 in LSCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPRD2 →	+0.389	+0.088	<.001	<.001	3	8
GBM	GATAD2B →	+0.387	+0.054	<.001	<.001	3	8
LSCC	GABPA →	+0.277	+0.081	<.001	<.001	3	7
LUAD	BCLAF1 →	+0.206	+0.051	<.001	<.001	3	7
LSCC	PHF3 →	+0.293	+0.061	<.001	.001	3	7
LSCC	POGZ →	+0.350	+0.069	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000055 vs RPRD2 — LSCC

Explore this scatter interactively →