Ribosomal large subunit export from nucleus

Across TCGA pan-cancer cohorts, RNA activity of the Ribosomal large subunit export from nucleus pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher Ribosomal large subunit export from nucleus pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and UCS, show the opposite pattern, with higher activity associated with better survival.

READ, ACC, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Tertile	II,III,IV	1.000	0.337	<.001	73	view →
ACC	DFS	Median	All	0.273	0.606	.001	40	view →
UCS	OS	Quartile	III,IV	0.773	0.311	.002	26	view →
UCEC	DFS	Tertile	All	0.797	0.883	.012	26	view →
LGG	OS	Tertile	All	0.892	0.756	<.001	20	view →
SKCM	DFS	Median	All	0.243	0.167	.008	20	view →
KIRC	DFS	Tertile	IV	0.182	0.448	.014	16	view →
MESO	DFS	Tertile	IV	0.138	0.580	.013	15	view →
STAD	DFS	Quartile	All	0.487	0.673	.026	13	view →
LUAD	DFS	Quartile	III,IV	0.220	0.748	<.001	12	view →
LIHC	OS	Quartile	All	0.635	0.826	.004	10	view →
KIRP	DFS	Quartile	All	0.508	0.810	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0000055–READ (OS)

Open the READ breakdown →