Ribosomal large subunit export from nucleus

Across TCGA patient cohorts, RNA activity of the Ribosomal large subunit export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBL2, UBE2C, and CDKN3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal large subunit export from nucleus activity versus MYBL2 in LUAD (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MYBL2 →	+1.313	+0.292	<.001	<.001	3	9
LUAD	UBE2C →	+1.466	+0.334	<.001	<.001	3	9
LUAD	CDKN3 →	+1.115	+0.318	<.001	<.001	3	8
LUAD	GINS1 →	+0.900	+0.322	<.001	<.001	3	8
LUAD	CENPI →	+0.983	+0.261	<.001	<.001	3	8
LUAD	NCAPG →	+1.110	+0.330	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000055 vs MYBL2 — LUAD

Explore this scatter interactively →