Ribosomal large subunit export from nucleus

Across TCGA cell cohorts, RNA activity of the Ribosomal large subunit export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF233, ASB14, and SPDYA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF233 grouped by Ribosomal large subunit export from nucleus-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF233 →	+0.943	+0.319	<.001	<.001	3	6
BREAST	ASB14 →	+0.178	+0.107	.006	.002	3	5
LUNG_SCLC	SPDYA →	+0.418	+0.170	<.001	.003	3	4
LARGE_INTESTINE	ZNF235 →	+0.834	+0.108	<.001	.001	3	4
LARGE_INTESTINE	STK36 →	+0.976	+0.107	.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF14 →	+0.933	+0.180	.004	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF233 by Ribosomal large subunit export from nucleus activity — STOMACH

Explore this box plot interactively →