Ribosomal large subunit export from nucleus

Across TCGA cell cohorts, RNA activity of the Ribosomal large subunit export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM18, CTXN1, and TEX2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosomal large subunit export from nucleus activity versus TMEM18 in LUNG_SCLC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMEM18 →	+0.706	+0.076	<.001	<.001	3	4
LUNG_SCLC	CTXN1 →	+1.619	+0.074	<.001	<.001	3	4
PANCREAS	TEX2 →	-0.862	-0.115	.003	.006	3	4
PANCREAS	LRIG1 →	-2.597	-0.169	.004	.001	3	4
BLOOD_Leukemia	DYNC2I2 →	+0.693	+0.067	.006	.002	3	4
BONE	FDXACB1 →	+0.815	+0.093	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000055 vs TMEM18 — LUNG_SCLC

Explore this scatter interactively →