Urea cycle

Across TCGA patient cohorts, RNA activity of the Urea cycle pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCR2, FFAR2, and FCGR3B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urea cycle activity versus CXCR2 in LSCC (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CXCR2 →	+0.822	+0.134	<.001	<.001	3	5
LSCC	FFAR2 →	+1.107	+0.132	<.001	.001	3	4
LSCC	FCGR3B →	+1.254	+0.173	<.001	<.001	3	4
LSCC	CXCR1 →	+1.122	+0.206	<.001	<.001	3	4
PDAC	CEACAM4 →	+0.443	+0.185	.001	.001	3	4
PDAC	HNRNPA1L2 →	-0.252	-0.162	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000050 vs CXCR2 — LSCC

Explore this scatter interactively →