Urea cycle

Across TCGA cell cohorts, RNA activity of the Urea cycle pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF480, GDF11, and FAM151B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF480 grouped by Urea cycle-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF480 →	+0.718	+1.141	.001	.005	3	4
BLOOD_Leukemia	GDF11 →	+1.072	+1.016	.006	.006	3	4
BONE	FAM151B →	+0.912	+1.497	.002	<.001	3	4
BONE	ZNF84 →	+1.507	+1.468	.007	.001	3	4
BONE	KLF1 →	+0.460	+1.647	.008	.002	3	3
OESOPHAGUS	H3C8 →	+0.566	+1.019	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF480 by Urea cycle activity — LUNG_SCLC

Explore this box plot interactively →