Urea cycle

Across TCGA cell cohorts, RNA activity of the Urea cycle pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1B1, MAFG, and PMS2P7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AKR1B1 grouped by Urea cycle-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	AKR1B1 →	+0.135	+0.249	.006	.008	3	3
UPPER_AERODIGESTIVE_TRACT	MAFG →	+0.138	+0.454	<.001	.008	3	3
UPPER_AERODIGESTIVE_TRACT	PMS2P7 →	+0.158	+0.454	.006	.008	3	3
SOFT_TISSUE	KSR2 →	+0.177	+0.585	.002	.001	2	4
SOFT_TISSUE	OR11G2 →	+0.286	+0.658	.008	.007	3	3
CNS	EPDR1 →	-0.294	-0.345	.009	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AKR1B1 by Urea cycle activity — BONE

Explore this box plot interactively →