Mitotic spindle elongation

Across TCGA patient cohorts, RNA activity of the Mitotic spindle elongation pathway is significantly associated with the RNA expression of multiple genes, with the SARC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPI, NCAPH, and KIF18A, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic spindle elongation activity versus CENPI in SARC (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	CENPI →	+1.382	+0.155	<.001	<.001	3	34
THYM	NCAPH →	+2.081	+0.118	<.001	<.001	3	34
THYM	KIF18A →	+1.579	+0.116	<.001	<.001	3	34
SARC	KIF23 →	+1.897	+0.162	<.001	<.001	3	34
THYM	SKA3 →	+1.673	+0.095	<.001	<.001	3	34
SARC	CKAP2L →	+1.867	+0.152	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000022 vs CENPI — SARC

Explore this scatter interactively →