Mitotic spindle elongation

Across TCGA patient cohorts, RNA activity of the Mitotic spindle elongation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, CEP152, and FBXO5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic spindle elongation activity versus GINS1 in BRCA (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GINS1 →	+0.952	+0.508	<.001	<.001	3	9
OV	CEP152 →	+0.738	+0.501	.001	.002	3	9
BRCA	FBXO5 →	+0.912	+0.566	<.001	<.001	3	9
BRCA	LMNB1 →	+0.964	+0.624	<.001	<.001	3	9
BRCA	KIF14 →	+1.198	+0.613	<.001	<.001	3	9
BRCA	NCAPH →	+1.034	+0.618	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000022 vs GINS1 — BRCA

Explore this scatter interactively →