ZZZ3

Across TCGA patient cohorts, ZZZ3 mutation is significantly associated with the RNA expression of many other genes, with 2,469 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZZZ3-associated genes across cancer lineages are SLC2A8, RNU7-129P, and RN7SL326P. Each is linked with ZZZ3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZZZ3-to-partner and partner-to-ZZZ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC2A8 grouped by ZZZ3-low versus ZZZ3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZZZ3→partner) and Y-score (partner→ZZZ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SLC2A8 →	+0.565	+3.333	.005	.005	3	2
LUSC	RNU7-129P →	+0.229	+3.291	.001	.005	3	2
LUSC	RN7SL326P →	+0.122	+2.804	<.001	.003	3	2
LUSC	MRPS31P1 →	+0.117	+3.177	.006	.002	3	2
LUAD	ADIPOR1P1 →	+0.055	+4.247	<.001	<.001	3	2
SARC	RNY1P1 →	+0.325	+5.380	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,469 associations by consensus.

SLC2A8 by ZZZ3 expression — LUSC

Explore this box plot interactively →