ZZEF1

Across TCGA cell cohorts, ZZEF1 mutation is significantly associated with the RNA expression of many other genes, with 399 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZZEF1-associated genes across cancer lineages are KCNA6, FAM193A, and PIGY. Each is linked with ZZEF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZZEF1-to-partner and partner-to-ZZEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA6 grouped by ZZEF1-low versus ZZEF1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZZEF1→partner) and Y-score (partner→ZZEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCNA6 →	+1.065	+3.648	.003	.002	3	3
SKIN	FAM193A →	+0.657	+3.299	.001	.004	3	3
BLOOD_Myeloma	PIGY →	+0.846	+4.807	.001	.006	3	2
SOFT_TISSUE	APOBEC3A →	+0.095	+4.304	.002	<.001	3	2
SOFT_TISSUE	RBBP8NL →	+0.009	+2.602	.002	.009	3	2
SOFT_TISSUE	H4C4 →	+0.431	+3.629	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 399 associations by consensus.

KCNA6 by ZZEF1 expression — BLOOD_Leukemia

Explore this box plot interactively →