ZW10

Across TCGA pan-cancer cohorts, ZW10 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZW10 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZW10 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZW10 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where ZW10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.885	0.632	.022	11	view →
CCRCC	DFS	Median	All	0.822	0.647	.016	6	view →
LUAD	DFS	Quartile	III,IV	1.000	0.550	.030	4	view →
PDAC	OS	Tertile	III,IV	0.185	0.623	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZW10–HNSC (OS)

Open the HNSC breakdown →