ZW10

Across TCGA pan-cancer cohorts, ZW10 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ZW10’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZW10 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZW10 is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

COAD, LUAD, and HNSC are the cancer types where ZW10 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZW10 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+0.232	<.001	10	view →
LUAD	Male	III,IV	+0.352	<.001	9	view →
HNSC	All	All	+0.115	<.001	9	view →
LSCC	Male	All	+0.356	<.001	8	view →
CCRCC	Male	III,IV	−0.123	<.001	7	view →
PDAC	Female	All	−0.274	<.001	5	view →
OV	All	All	+0.399	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ZW10–COAD

Open the COAD breakdown →