Across TCGA cell cohorts, ZSWIM8 mutation is significantly associated with the RNA expression of many other genes, with 748 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZSWIM8-associated genes across cancer lineages are SLC15A5, FAM187B, and GLT6D1. Each is linked with ZSWIM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSWIM8-to-partner and partner-to-ZSWIM8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM8→partner) and Y-score (partner→ZSWIM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SLC15A5 →	+0.006	+4.643	<.001	.008	3	2
SKIN	FAM187B →	+0.063	+3.684	<.001	.006	3	2
URINARY_TRACT	GLT6D1 →	+0.026	+5.087	<.001	.004	3	1
URINARY_TRACT	OR2J2 →	+0.013	+5.087	<.001	.004	3	1
BLOOD_Myeloma	SERPINA4 →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 748 associations by consensus.

Exploration

ZSWIM8 survival (RNA) · tumor vs normal (RNA) · all ZSWIM8 data types