ZSWIM5

Across TCGA patient cohorts, ZSWIM5 mutation is significantly associated with the RNA expression of many other genes, with 2,889 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSWIM5-associated genes across cancer lineages are ATP5F1A, HINT1, and MPV17L2. Each is linked with ZSWIM5 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZSWIM5-to-partner and partner-to-ZSWIM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5F1A grouped by ZSWIM5-low versus ZSWIM5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM5→partner) and Y-score (partner→ZSWIM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ATP5F1A →	+0.475	+3.483	.002	.002	3	5
UCEC	HINT1 →	+0.438	+2.743	.002	.002	3	4
LUSC	MPV17L2 →	+0.441	+3.196	.008	.009	3	4
UCEC	EI24 →	+0.404	+2.070	.005	.001	3	3
UCEC	MRPL39 →	+0.392	+2.111	.002	.003	3	3
UCEC	NUP205 →	+0.528	+2.459	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,889 associations by consensus.

ATP5F1A by ZSWIM5 expression — LUSC

Explore this box plot interactively →