ZSWIM4

Across TCGA patient cohorts, ZSWIM4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,149 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ZSWIM4-associated genes across cancer lineages are UPB1, C22orf31, and IFT27. Each is linked with ZSWIM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSWIM4-to-partner and partner-to-ZSWIM4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZSWIM4 versus UPB1 in CCRCC, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM4→partner) and Y-score (partner→ZSWIM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	UPB1 →	+1.236	+1.336	.009	.001	3	1
CCRCC	C22orf31 →	+0.509	+1.418	.003	.001	3	1
CCRCC	IFT27 →	-0.372	-0.888	.008	.005	3	1
CCRCC	PCK2 →	+0.615	+0.754	<.001	.007	3	1
CCRCC	TRPC4AP →	-0.310	-1.096	.005	.001	3	1
CCRCC	ZMYND8 →	-0.857	-1.124	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,149 associations by consensus.

ZSWIM4 vs UPB1 — CCRCC

Explore this scatter interactively →