ZSWIM3

Across TCGA patient cohorts, ZSWIM3 mutation is significantly associated with the RNA expression of many other genes, with 4,030 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSWIM3-associated genes across cancer lineages are BAG3, BUB3, and PDXK. Each is linked with ZSWIM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZSWIM3-to-partner and partner-to-ZSWIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BAG3 grouped by ZSWIM3-low versus ZSWIM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM3→partner) and Y-score (partner→ZSWIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BAG3 →	+0.686	+2.502	<.001	.001	3	3
UCEC	BUB3 →	+0.501	+2.210	<.001	.001	3	3
UCEC	PDXK →	+0.434	+2.361	.006	.003	3	3
UCEC	LEO1 →	+0.539	+2.403	<.001	<.001	3	3
SKCM	NDEL1 →	+0.472	+2.951	.001	<.001	3	3
UCEC	PPP2R2D →	+0.316	+3.970	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,030 associations by consensus.

BAG3 by ZSWIM3 expression — UCEC

Explore this box plot interactively →