ZSCAN5A

Across TCGA patient cohorts, ZSCAN5A mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN5A-associated genes across cancer lineages are Lck, MEK1, and mTOR. Each is linked with ZSCAN5A in more than 2 cancer types. Because this analysis shows association rather than direction, both ZSCAN5A-to-partner and partner-to-ZSCAN5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by ZSCAN5A-low versus ZSCAN5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN5A→partner) and Y-score (partner→ZSCAN5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.240	+1.700	.004	.044	3	3
UCEC	MEK1 →	+0.350	+1.700	.024	.044	3	2
UCEC	mTOR →	-0.208	-2.222	.002	.011	3	2
UCEC	S6 →	-0.287	-2.222	.011	.011	3	2
UCEC	4E-BP1 →	+0.237	+2.222	.039	.011	3	2
SKCM	HER3 →	+0.411	+3.000	.026	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Lck by ZSCAN5A expression — UCEC

Explore this box plot interactively →