ZSCAN5A

Across TCGA cell cohorts, ZSCAN5A mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZSCAN5A-associated genes across cancer lineages are DEFA3, MAGEB4, and OBP2A. Each is linked with ZSCAN5A in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSCAN5A-to-partner and partner-to-ZSCAN5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA3 grouped by ZSCAN5A-low versus ZSCAN5A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN5A→partner) and Y-score (partner→ZSCAN5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DEFA3 →	+0.733	+4.867	<.001	.009	3	2
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	OBP2A →	+0.112	+2.878	<.001	.009	3	1
LARGE_INTESTINE	MS4A3 →	+0.100	+3.584	<.001	.003	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	C12orf40 →	+0.007	+3.514	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

DEFA3 by ZSCAN5A expression — BLOOD_Lymphoma

Explore this box plot interactively →