ZSCAN10

Across TCGA patient cohorts, ZSCAN10 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN10-associated genes across cancer lineages are 4E-BP1, PCNA, and GSK3-a-b. Each is linked with ZSCAN10 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZSCAN10-to-partner and partner-to-ZSCAN10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ZSCAN10-low versus ZSCAN10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN10→partner) and Y-score (partner→ZSCAN10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1 →	+0.378	+3.169	.005	.018	3	4
SKCM	PCNA →	+0.306	+2.700	<.001	.006	3	3
SKCM	GSK3-a-b →	+0.175	+3.033	.012	.017	3	3
SKCM	eEF2 →	+0.393	+2.824	.007	.034	3	2
UCEC	N-Cadherin →	+0.162	+1.874	.030	.049	3	2
UCEC	Stathmin →	+0.100	+1.362	.038	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

4E-BP1 by ZSCAN10 expression — SKCM

Explore this box plot interactively →