Across TCGA patient cohorts, ZPBP2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZPBP2-associated genes across cancer lineages are JNK2, Ku80, and MEK1. Each is linked with ZPBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZPBP2-to-partner and partner-to-ZPBP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZPBP2→partner) and Y-score (partner→ZPBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.257	+2.817	.005	.036	3	1
UCEC	Ku80 →	+0.333	+1.887	.002	.031	3	1
UCEC	MEK1 →	+0.482	+3.584	.004	.002	3	1
UCEC	mTOR_pS2448 →	-0.173	-3.156	.013	.018	3	1
UCEC	Notch1 →	+0.243	+2.469	<.001	.010	3	1
UCEC	PDCD4 →	-0.772	-3.449	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

ZPBP2 survival (RNA) · tumor vs normal (RNA) · all ZPBP2 data types