Across TCGA pan-cancer cohorts, ZPBP2 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ZPBP2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ZPBP2 RNA is repressed in tumor relative to normal tissue. In most cancer types ZPBP2 is over-expressed in tumor, although a few such as LUSC and PRAD show the opposite, repressed pattern.

LUSC, PRAD, and ESCA are the cancer types where ZPBP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZPBP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	III,IV	−0.145	.010	2	view →
PRAD	All	All	−0.052	.019	2	view →
ESCA	Female	All	+0.070	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ZPBP2 RNA expression & survival · all ZPBP2 data types