ZPBP

Across TCGA patient cohorts, ZPBP mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZPBP-associated genes across cancer lineages are MEK1, 14-3-3_beta, and FASN. Each is linked with ZPBP in more than 1 cancer types. Because this analysis shows association rather than direction, both ZPBP-to-partner and partner-to-ZPBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZPBP-low versus ZPBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZPBP→partner) and Y-score (partner→ZPBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.433	+2.807	.004	.003	3	2
UCEC	14-3-3_beta →	-0.110	-3.295	.008	.009	3	1
UCEC	FASN →	+0.423	+2.321	.009	.006	3	1
UCEC	ACC1 →	+0.417	+2.321	.005	.006	3	1
UCEC	HSP70 →	-0.334	-2.990	.044	.036	3	1
UCEC	p62 Lck ligand →	+0.443	+3.594	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MEK1 by ZPBP expression — UCEC

Explore this box plot interactively →