ZP4

Across TCGA patient cohorts, ZP4 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZP4-associated genes across cancer lineages are ATM, Cyclin-B1, and EGFR_pY1068. Each is linked with ZP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZP4-to-partner and partner-to-ZP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZP4-low versus ZP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZP4→partner) and Y-score (partner→ZP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.482	-1.584	.006	.036	3	3
UCEC	Cyclin-B1 →	+0.572	+3.321	.009	.010	3	2
UCEC	EGFR_pY1068 →	-0.243	-2.502	.013	.002	3	2
UCEC	FOXO3a_pS318_S321 →	-0.098	-1.797	.045	.025	3	2
UCEC	ACC1 →	+0.326	+3.013	.022	.018	3	2
UCEC	INPP4B →	-0.252	-2.459	.047	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ATM by ZP4 expression — UCEC

Explore this box plot interactively →