ZP4

Across TCGA pan-cancer cohorts, ZP4 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated ZP4 data layer compared with 9 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ZP4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZP4 expression acts as an unfavorable survival marker, although some lineages such as UVM and CESC show a favorable association.

UVM, LIHC, and KIRC are the cancer types where ZP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.779	0.425	<.001	95	view →
LIHC	DFS	Tertile	II,III,IV	0.070	0.420	<.001	54	view →
KIRC	DFS	Tertile	All	0.666	0.828	<.001	54	view →
CESC	DFS	Tertile	II,III,IV	0.779	0.365	.002	52	view →
ESCA	OS	Median	IV	0.698	0.222	.006	30	view →
CHOL	OS	Tertile	All	0.200	0.740	.002	27	view →
KICH	DFS	Tertile	All	0.218	0.889	<.001	24	view →
UCS	OS	Median	II,III,IV	0.590	0.261	.015	18	view →
TGCT	DFS	Median	All	0.919	0.745	.007	14	view →
THCA	OS	Tertile	IV	0.626	1.000	.002	9	view →
READ	DFS	Tertile	II,III,IV	0.614	0.829	.048	9	view →
ACC	DFS	Tertile	All	0.204	0.658	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

ZP4–UVM (DFS)

Open the UVM breakdown →