ZP1

Across TCGA patient cohorts, ZP1 mutation is significantly associated with the RNA expression of many other genes, with 3,015 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZP1-associated genes across cancer lineages are AP1S3, MRPL39, and BOLA3. Each is linked with ZP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZP1-to-partner and partner-to-ZP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AP1S3 grouped by ZP1-low versus ZP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZP1→partner) and Y-score (partner→ZP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AP1S3 →	+0.631	+1.890	<.001	<.001	3	2
UCEC	MRPL39 →	+0.487	+2.443	<.001	<.001	3	2
UCEC	BOLA3 →	+0.383	+3.000	<.001	<.001	3	2
UCEC	LRR1 →	+0.640	+2.115	<.001	<.001	3	2
UCEC	DEPDC4 →	+0.257	+2.694	<.001	<.001	3	2
UCEC	GPX4 →	+0.386	+2.169	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,015 associations by consensus.

AP1S3 by ZP1 expression — UCEC

Explore this box plot interactively →