ZP1

Across TCGA pan-cancer cohorts, ZP1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZP1 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where ZP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+0.787	<.001	7	view →
COAD	All	III,IV	−0.173	.010	7	view →
KIRP	Male	All	+0.084	.001	6	view →
LUSC	All	All	+0.181	.002	4	view →
THCA	All	IV	−0.132	.013	3	view →
PRAD	All	All	+0.754	<.001	2	view →
CHOL	All	All	+0.200	.028	2	view →
BRCA	All	All	−0.137	.020	2	view →
KICH	Female	All	−0.052	.004	2	view →
LIHC	Male	All	+0.025	.011	2	view →
HNSC	Male	III,IV	+0.241	.048	1	view →
LUAD	All	All	+0.098	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZP1–KIRC

Open the KIRC breakdown →