ZP1

Across TCGA cell cohorts, ZP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,976 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ZP1-associated GO terms across cancer lineages are Negative regulation of fertilization, Prevention of polyspermy, and Regulation of plasminogen activation. Each is linked with ZP1 in more than 9 cancer types. Because this analysis shows association rather than direction, both ZP1-to-partner and partner-to-ZP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of fertilization grouped by ZP1-low versus ZP1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZP1→partner) and Y-score (partner→ZP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of fertilization →	-0.355	-1.408	<.001	<.001	3	10
LUNG_SCLC	Prevention of polyspermy →	-0.355	-1.408	<.001	<.001	3	10
BONE	Regulation of plasminogen activation →	+0.276	+0.546	<.001	.004	3	7
LUNG_SCLC	Protein secretion →	+0.097	+0.938	<.001	.008	3	7
BONE	Positive regulation of stress fiber assembly →	+0.169	+0.345	<.001	.002	3	7
BONE	Organic cation transport →	-0.078	-0.522	<.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,976 associations by consensus.

Negative regulation of fertilization by ZP1 expression — LUNG_SCLC

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