ZP1

Across TCGA cell cohorts, ZP1 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible ZP1-associated genes across cancer lineages are IFNK, OR52N1, and CSMD1. Each is linked with ZP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZP1-to-partner and partner-to-ZP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNK grouped by ZP1-low versus ZP1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZP1→partner) and Y-score (partner→ZP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	IFNK →	+0.016	+5.139	<.001	<.001	3	1
PANCREAS	OR52N1 →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	CSMD1 →	+0.746	+4.011	.002	.009	3	1
PANCREAS	FFAR3 →	+0.028	+4.237	.009	.006	3	1
PANCREAS	NCR1 →	+0.043	+4.786	<.001	.001	3	1
PANCREAS	OR52M1 →	+0.020	+4.614	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

IFNK by ZP1 expression — PANCREAS

Explore this box plot interactively →