ZNRF4

Across TCGA patient cohorts, ZNRF4 protein abundance is significantly associated with the RNA expression of many other genes, with 7,220 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ZNRF4-associated genes across cancer lineages are NENF, GCNA, and LRFN2. Each is linked with ZNRF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNRF4-to-partner and partner-to-ZNRF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNRF4 versus NENF in OV, with a Pearson correlation of -0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNRF4→partner) and Y-score (partner→ZNRF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NENF →	-0.854	-1.336	.006	.004	3	2
OV	GCNA →	+0.763	+1.480	.001	<.001	3	2
GBM	LRFN2 →	+1.002	+0.523	<.001	<.001	3	2
OV	SLFNL1 →	+1.074	+1.549	.003	.001	3	2
OV	SELP →	+1.458	+1.320	.002	.008	2	3
GBM	TMEM125 →	+1.292	+0.485	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,220 associations by consensus.

ZNRF4 vs NENF — OV

Explore this scatter interactively →