ZNRF4

Across TCGA pan-cancer cohorts, ZNRF4 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated ZNRF4 data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ZNRF4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNRF4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PRAD show a favorable association.

READ, MESO, and BLCA are the cancer types where ZNRF4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Tertile	All	0.309	0.859	<.001	72	view →
MESO	DFS	Tertile	IV	0.079	0.414	.004	63	view →
BLCA	DFS	Tertile	All	0.171	0.357	.001	54	view →
LUSC	DFS	Tertile	II,III,IV	0.154	0.684	<.001	45	view →
KIRC	OS	Tertile	All	0.728	0.822	<.001	42	view →
ACC	OS	Tertile	All	0.216	0.728	.004	36	view →
SCLC	DFS	Quartile	II,III,IV	0.228	0.848	.002	24	view →
STAD	DFS	Tertile	IV	0.130	0.528	.002	23	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	21	view →
GBM	OS	Median	All	0.336	0.475	.009	18	view →
UCEC	OS	Median	IV	0.906	0.624	.020	16	view →
ESCA	OS	Median	II,III,IV	0.403	0.919	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

ZNRF4–READ (DFS)

Open the READ breakdown →