ZNRF4

Across TCGA patient cohorts, ZNRF4 mutation is significantly associated with the RNA expression of many other genes, with 2,199 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNRF4-associated genes across cancer lineages are FAM136A, ANKRD33B-AS1, and ACBD5. Each is linked with ZNRF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNRF4-to-partner and partner-to-ZNRF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM136A grouped by ZNRF4-low versus ZNRF4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNRF4→partner) and Y-score (partner→ZNRF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FAM136A →	+0.360	+3.497	.009	.002	3	3
READ	ANKRD33B-AS1 →	+0.187	+6.681	<.001	<.001	3	3
UCEC	ACBD5 →	+0.703	+2.415	<.001	.003	3	3
UCEC	TMEM33 →	+0.494	+3.480	.007	.002	3	3
UCEC	TMED5 →	+0.597	+2.732	.004	.003	3	3
UCEC	KDSR →	+0.511	+3.593	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,199 associations by consensus.

FAM136A by ZNRF4 expression — SKCM

Explore this box plot interactively →