ZNRF4

Across TCGA patient cohorts, ZNRF4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNRF4-associated genes across cancer lineages are eIF4E, SF2, and ACC1. Each is linked with ZNRF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNRF4-to-partner and partner-to-ZNRF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNRF4-low versus ZNRF4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNRF4→partner) and Y-score (partner→ZNRF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.199	+3.459	.023	.005	3	2
SKCM	SF2 →	-0.193	-2.321	.004	.035	3	2
UCEC	ACC1 →	+0.391	+3.183	.011	.009	3	2
UCEC	MSH2 →	-0.330	-3.143	<.001	.018	3	2
UCEC	Annexin-1 →	+0.616	+2.479	.005	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.634	+2.999	.011	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

eIF4E by ZNRF4 expression — SKCM

Explore this box plot interactively →