ZNRF4

Across TCGA cell cohorts, ZNRF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 148 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ZNRF4-associated GO terms across cancer lineages are Positive regulation of protein localization to synapse, Negative regulation of T cell differentiation in thymus, and Deltoid tuberosity development. Each is linked with ZNRF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNRF4-to-partner and partner-to-ZNRF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein localization to synapse grouped by ZNRF4-low versus ZNRF4-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNRF4→partner) and Y-score (partner→ZNRF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of protein localization to synapse →	+0.165	+0.013	.008	.009	3	3
CNS	Negative regulation of T cell differentiation in thymus →	-0.186	-0.011	.001	.009	3	2
CNS	Deltoid tuberosity development →	-0.666	-0.014	.003	.001	3	2
LUNG_SCLC	Bundle of His cell to Purkinje myocyte communication →	-0.197	-0.013	.001	.009	3	2
SOFT_TISSUE	Exocytic process →	+0.059	+0.010	<.001	.008	3	1
SOFT_TISSUE	Glutamate secretion →	+0.250	+0.010	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 148 associations by consensus.

Positive regulation of protein localization to synapse by ZNRF4 expression — LUNG_SCLC

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