ZNRF4

Across TCGA cell cohorts, ZNRF4 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNRF4-associated genes across cancer lineages are VCY, DEFB118, and IL25. Each is linked with ZNRF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNRF4-to-partner and partner-to-ZNRF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCY grouped by ZNRF4-low versus ZNRF4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNRF4→partner) and Y-score (partner→ZNRF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	VCY →	+0.722	+3.672	<.001	.006	3	1
BREAST	DEFB118 →	+0.026	+4.196	<.001	.006	3	1
BREAST	IL25 →	+0.023	+3.672	<.001	.006	3	1
BREAST	TGM6 →	+0.021	+4.312	<.001	.001	3	1
BREAST	OR52A1 →	+0.025	+5.087	<.001	<.001	3	1
SKIN	KRTAP4-6 →	+0.049	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

VCY by ZNRF4 expression — BREAST

Explore this box plot interactively →