Across TCGA cell cohorts, ZNRF3 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNRF3-associated genes across cancer lineages are KRTAP5-4, DTHD1, and GPR32. Each is linked with ZNRF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNRF3-to-partner and partner-to-ZNRF3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNRF3→partner) and Y-score (partner→ZNRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP5-4 →	+0.101	+4.977	<.001	.007	3	2
CNS	DTHD1 →	+0.027	+4.044	<.001	.003	3	2
SOFT_TISSUE	GPR32 →	+0.044	+4.295	<.001	.002	3	1
SOFT_TISSUE	TBC1D21 →	+0.014	+4.392	<.001	.004	3	1
SOFT_TISSUE	SDR42E2 →	+0.019	+4.459	<.001	.001	3	1
SOFT_TISSUE	TMEM211 →	+0.040	+4.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Exploration

ZNRF3 survival (RNA) · tumor vs normal (RNA) · all ZNRF3 data types