ZNRF2

Across TCGA patient cohorts, ZNRF2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNRF2-associated genes across cancer lineages are EGFR_pY1068, ACC_pS79, and ACC1. Each is linked with ZNRF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNRF2-to-partner and partner-to-ZNRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNRF2-low versus ZNRF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNRF2→partner) and Y-score (partner→ZNRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.318	-3.584	.002	.002	3	1
UCEC	ACC_pS79 →	+0.485	+3.321	<.001	.009	3	1
UCEC	ACC1 →	+0.485	+3.183	.001	.009	3	1
UCEC	p38-MAPK →	-0.199	-1.700	.004	.044	3	1
UCEC	p70-S6K_pT389 →	-0.170	-2.321	.034	.033	3	1
UCEC	PCNA →	+0.224	+3.169	.014	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by ZNRF2 expression — UCEC

Explore this box plot interactively →