ZNRF2

Across TCGA pan-cancer cohorts, ZNRF2 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ZNRF2’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ZNRF2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNRF2 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

BLCA, HNSC, and THCA are the cancer types where ZNRF2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNRF2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+0.800	.001	11	view →
HNSC	Female	III,IV	+1.137	<.001	10	view →
THCA	Female	III,IV	+0.683	<.001	9	view →
COAD	All	All	−0.502	<.001	9	view →
KICH	All	II,III,IV	−0.923	<.001	8	view →
BRCA	All	II,III,IV	+0.838	<.001	8	view →
STAD	All	II,III,IV	+0.669	<.001	7	view →
UCEC	All	II,III,IV	+0.842	.007	6	view →
LUAD	Male	II,III,IV	+0.839	<.001	6	view →
LIHC	Male	All	+0.671	<.001	6	view →
READ	All	All	−0.492	.001	6	view →
LUSC	Male	All	+0.587	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ZNRF2–BLCA

Open the BLCA breakdown →