ZNRD2

Across TCGA patient cohorts, ZNRD2 mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNRD2-associated genes across cancer lineages are HMGB1P50, RNU6-788P, and MIR4692. Each is linked with ZNRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNRD2-to-partner and partner-to-ZNRD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P50 grouped by ZNRD2-low versus ZNRD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNRD2→partner) and Y-score (partner→ZNRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGB1P50 →	+0.201	+2.735	.002	.006	3	2
UCEC	RNU6-788P →	+0.256	+4.069	<.001	.008	3	2
SKCM	MIR4692 →	+0.547	+6.080	<.001	.002	3	2
UCEC	NUTF2P8 →	+0.178	+3.661	<.001	.001	3	1
UCEC	MIR4727 →	+0.447	+3.551	<.001	.004	3	1
UCEC	CLEC3A →	+0.914	+3.505	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

HMGB1P50 by ZNRD2 expression — UCEC

Explore this box plot interactively →